Issue 15, 2013
From the journal:

Polymer Chemistry

PEGylation of fluoridated hydroxyapatite (FAp):Ln3+nanorods for cell imaging†

Xiaoyong Zhang,‡a   Junfeng Hui,‡*b   Bin Yang,a   Yong Yang,a   Daidi Fan,b   Meiying Liu,c   Lei Tao*a  and  Yen Wei*a  

* Corresponding authors

a Department of Chemistry, Tsinghua University, Beijing, P. R. China
E-mail: leitao@mail.tsinghua.edu.cn, weiyen@tsinghua.edu.cn

b Shaanxi Key Laboratory of Degradable Biomedical Materials, Shanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, P. R. China
E-mail: huijunfeng@126.com

c Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Laboratory of New Materials, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Abstract

PEGylation is a popular approach for the surface functionalization of nanoparticles to achieve improved properties and better performance. Herein, we developed a facile method for surface PEGylation of hydrophobic fluoridated hydroxyapatite (FAp):Ln3+ (Ln = Eu or Tb) nanorods via hydrophobic interactions between oleic acid and amphiphilic synthetic copolymers, which were synthesized through reversible addition-fragmentation chain transfer (RAFT) polymerization using stearyl methacrylate (SMA) and poly(ethylene glycol) methacrylate (PEGMA) as monomers. Our results demonstrated that the morphology and fluorescent properties of the FAp nanorods are not significantly changed by the PEGylation procedure, and the resulting FAp nanorods were found to be stable in aqueous solution. More importantly, these PEGylated FAp nanorods are biocompatible with cells and could be utilized for cell imaging applications. Therefore, we believe that the method described in this work is a simple, efficient and general strategy for the surface PEGylation of hydrophobic nanoparticles.

Graphical abstract: PEGylation of fluoridated hydroxyapatite (FAp):Ln3+ nanorods for cell imaging

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C3PY00489A
Article type
Paper
Submitted
16 Apr 2013
Accepted
06 May 2013
First published
07 May 2013

Polym. Chem., 2013,4, 4120-4125

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PEGylation of fluoridated hydroxyapatite (FAp):Ln3+ nanorods for cell imaging

X. Zhang, J. Hui, B. Yang, Y. Yang, D. Fan, M. Liu, L. Tao and Y. Wei, Polym. Chem., 2013, 4, 4120 DOI: 10.1039/C3PY00489A

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