Issue 3, 2013
From the journal:

Natural Product Reports

Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

Dana K. Winter,a   David L. Slomanb  and  John A. Porco Jr.*a  

* Corresponding authors

a Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA
E-mail: porco@bu.edu
Fax: (+1) 617-358-2847
Tel: (+1) 617-353-2493

b Merck Research Laboratories-Boston: 3-120, 33 Avenue Louis Pasteur, Boston, MA 02115
E-mail: david_sloman@merck.com
Tel: (+1) 617-992-2063

Abstract

Covering: 1972 to 2012

Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated, angular hexacyclic frameworks. In the last decade, this novel class of molecules has attracted noticeable attention from the synthetic and biological communities due to emerging reports of their potential use as antitumour agents. The aim of this article is to highlight the most recent developments of this subset of the xanthone family by detailing the innate challenges of the construction of this class of natural products, new synthetic approaches, and pharmacological data.

Graphical abstract: Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

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Article information

DOI
https://doi.org/10.1039/C3NP20122H
Article type
Highlight
Submitted
04 Dec 2012
First published
21 Jan 2013

Nat. Prod. Rep., 2013,30, 382-391

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Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

D. K. Winter, D. L. Sloman and J. A. Porco Jr., Nat. Prod. Rep., 2013, 30, 382 DOI: 10.1039/C3NP20122H

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