Issue 9, 2013
From the journal:

Food & Function

A health food high-peptide meal alleviates immunosuppression induced by hydrocortisone and cyclophosphamide in mice

Lv Yingjian,a   Huang Junming,*a   Cai Min,a   Li Chenyue,b   Zhang Dachao,c   Hu Yuanhuac  and  Li Zhia  

* Corresponding authors

a Center for Disease Control and Prevention of Guangdong Province, 160 Qun Xian Road, Pan Yu District, Guangzhou, China
E-mail: huangjunming@cdcp.org.cn
Tel: +86 20 31051228

b Perfect (China) Co., Ltd., Guangdong, Zhongshan-528402, China

c Committee of Health Care Consulation China Health Care Association, Beijing-100044, China

Abstract

This study set out to determine the immunomodulatory effects of a health food high-peptide meal in immunodeficient mice that was induced by either hydrocortisone (HY) or cyclophosphamide (CP). Five separate trials were performed in which animals were randomly divided into 5 groups of 12 mice for each experimental trial. Group 1 served as the vehicle control. Animals assigned to groups 3–5 (dose groups), were each administered once daily with 1.67, 3.33 or 6.67 g kg−1 body weight of a high-peptide meal, respectively, for 30 consecutive days. Animals from groups 2 to 5 that were included in trials 1 to 4, each received an intramuscular administration of HY at 40 mg kg−1 body weight on days 22, 24, 26, 28, 30. Animals from groups 2–5, in trial 5, each received an intraperitoneal administration of CP at 50 mg kg−1 body weight, on days 26 and 27. On day 31, all groups of mice were differentially screened for immunomodulatory activity following the conclusion of the above experiments. In HY-treated mice, the high-peptide meal accelerated the recovery of the phagocytic function of both macrophages and the reticuloendothelial system, and restored NK cell activity. In CP-treated mice, the high-peptide meal promoted a humoral immune response to sheep red blood cells (SRBCs). These results demonstrated the immunomodulatory effects of a high-peptide meal.

Graphical abstract: A health food high-peptide meal alleviates immunosuppression induced by hydrocortisone and cyclophosphamide in mice

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C3FO30230J
Article type
Paper
Submitted
01 Sep 2012
Accepted
09 Jun 2013
First published
10 Jun 2013

Food Funct., 2013,4, 1352-1359

Permissions

Request permissions

A health food high-peptide meal alleviates immunosuppression induced by hydrocortisone and cyclophosphamide in mice

L. Yingjian, H. Junming, C. Min, L. Chenyue, Z. Dachao, H. Yuanhua and L. Zhi, Food Funct., 2013, 4, 1352 DOI: 10.1039/C3FO30230J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements