Issue 33, 2013
From the journal:

Dalton Transactions

The vanadyl chelate bis(acetylacetonato)oxovanadium(iv) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-d-glucose by cultured human breast carcinoma cells†

Marvin W. Makinen,*a   Ravinder Bamba,a   Lynda Ikejimba,b   Christian Wietholt,‡b   Chin-Tu Chenb  and  Suzanne D. Conzenc  

* Corresponding authors

a Department of Biochemistry & Molecular Biology, The University of Chicago, Gordon Center for Integrative Science, 929 East 57th Street, Chicago, IL 60637, USA
E-mail: makinen@uchicago.edu
Fax: +001-773-702-0439
Tel: +001-773-702-1080

b Department of Radiology, The University of Chicago, Franklin-MacLean Research Institute, 5841 South Maryland Avenue, Chicago, IL 60637, USA

c Department of Medicine, Section on Hematology/Oncology, Knapp Center for Biomedical Discovery, The University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA

Abstract

Detection of breast cancer by positron emission tomography (PET) imaging with 2-(fluorine-18)-2-deoxy-D-glucose (FDG) as the tracer molecule is limited in part by both tumor dimension and metabolic activity. While some types of aggressive breast cancers are associated with a high capacity for FDG uptake, more indolent breast cancers are characterized by low FDG uptake. Moreover, detection of malignant lesions in most clinical settings requires tumor dimensions ≥10 mm. Development of a method to increase the fractional uptake of FDG by cancer tissue would provide a means to detect smaller tumors. However, there is no clinically available pharmacologic reagent known to enhance the preferential uptake of FDG by cancer tissue. Because the vanadyl (VO2+) chelate bis(acetylacetonato)oxovanadium(IV) [VO(acac)2] is known to enhance cellular uptake of glucose, we have investigated whether VO(acac)2 facilitates enhanced uptake of FDG by cultured human breast carcinoma cells. We observed that the fractional uptake of FDG by cultured human MDA-MB-231 carcinoma cells is increased in the presence of VO(acac)2 in a dose dependent manner. Preliminary results with xenograft tumors generated in severely compromised, immunodeficient (SCID) female mice showed that VO(acac)2 treatment of mice 3–4 h prior to FDG injection enhanced FDG uptake by the malignant tissue by a factor >2.0 compared with that by normal surrounding tissue.

Graphical abstract: The vanadyl chelate bis(acetylacetonato)oxovanadium(iv) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-d-glucose by cultured human breast carcinoma cells

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Article information

DOI
https://doi.org/10.1039/C3DT50549A
Article type
Paper
Submitted
28 Feb 2013
Accepted
25 Apr 2013
First published
25 Apr 2013

Dalton Trans., 2013,42, 11862-11867

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The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells

M. W. Makinen, R. Bamba, L. Ikejimba, C. Wietholt, C. Chen and S. D. Conzen, Dalton Trans., 2013, 42, 11862 DOI: 10.1039/C3DT50549A

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