A novel hydrazino-substituted naphthalimide-based fluorogenic probe for tert-butoxy radicals

Zhao Ma; Wei Sun; Laizhong Chen; Jing Li; Zhenzhen Liu; Haixiu Bai; Mengyuan Zhu; Lupei Du; Xiaodong Shi; Minyong Li

doi:10.1039/C3CC42052C

A novel hydrazino-substituted naphthalimide-based fluorogenic probe for tert-butoxy radicals†

Zhao Ma,^a Wei Sun,^a Laizhong Chen,^a Jing Li,^a Zhenzhen Liu,^a Haixiu Bai,^a Mengyuan Zhu,^a Lupei Du,^a Xiaodong Shi^b and Minyong Li*^a

Author affiliations

* Corresponding authors

^a Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China
E-mail: mli@sdu.edu.cn
Fax: +86-531-8838-2076
Tel: +86-531-8838-2076

^b C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV 26506, USA

Abstract

A novel fluorogenic probe for tert-butoxy radicals based on the hydrazino-naphthalimide system is reported. Interestingly, different regioisomers exhibited significantly different optical properties toward ROS, which suggested 4-hydrazinyl naphthalimide as a potential new platform for the in vitro and in cellulo detection of alkoxyl radicals.

Chemical Communications

A novel hydrazino-substituted naphthalimide-based fluorogenic probe for tert-butoxy radicals†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A novel hydrazino-substituted naphthalimide-based fluorogenic probe for tert-butoxy radicals

Social activity

Search articles by author

Spotlight

Advertisements