Issue 52, 2013

Exploring the differences between mouse mAβ1–42 and human hAβ1–42 for Alzheimer's disease related properties and neuronal cytotoxicity

Abstract

The differences between mouse mAβ1–42 and human hAβ1–42, explored using CD and fluorescence spectroscopy, transmission electron microscopy, ROS fluorescent assay, and neuronal cell viability, revealed that mAβ1–42 as a three-site mutant (R5G, Y10F and H13R) of hAβ1–42 altered the metal (copper and zinc) binding sites, reduced the proneness to form β-sheet structures and aggregated fibrils, alleviated the generation of ROS, and decreased the cytotoxicity, in contrast to hAβ1–42.

Graphical abstract: Exploring the differences between mouse mAβ1–42 and human hAβ1–42 for Alzheimer's disease related properties and neuronal cytotoxicity

Supplementary files

Article information

Article type
Communication
Submitted
29 Jan 2013
Accepted
03 May 2013
First published
09 May 2013

Chem. Commun., 2013,49, 5865-5867

Exploring the differences between mouse mAβ1–42 and human hAβ1–42 for Alzheimer's disease related properties and neuronal cytotoxicity

X. Lv, W. Li, Y. Luo, D. Wang, C. Zhu, Z. Huang and X. Tan, Chem. Commun., 2013, 49, 5865 DOI: 10.1039/C3CC40779A

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