Issue 41, 2013

P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation

Abstract

Solved crystal structures of P450 BM3 variants in complex with styrene provide on the molecular level a first explanation of how a positively charged surface residue inverts the enantiopreference of styrene epoxidation. The obtained insights into productive and non-productive styrene binding modes deepened our understanding of enantioselective epoxidation with P450 BM3.

Graphical abstract: P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation

Supplementary files

Article information

Article type
Communication
Submitted
19 Dec 2012
Accepted
04 Apr 2013
First published
05 Apr 2013

Chem. Commun., 2013,49, 4694-4696

P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation

A. Shehzad, S. Panneerselvam, M. Linow, M. Bocola, D. Roccatano, J. Mueller-Dieckmann, M. Wilmanns and U. Schwaneberg, Chem. Commun., 2013, 49, 4694 DOI: 10.1039/C3CC39076D

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