Issue 35, 2013
From the journal:

Chemical Communications

Controlling the rate of coiled coil driven membrane fusion†

Tingting Zheng,a   Jens Voskuhl,a   Frank Versluis,a   Harshal R. Zope,a   Itsuro Tomatsu,a   Hana Robson Marsdena  and  Alexander Kros*a  

* Corresponding authors

a Soft Matter Chemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands
E-mail: a.kros@chem.leidenuniv.nl

Abstract

Sets of complementary lipidated coiled-coil forming peptides that fuse membrane fusion have been designed. The influence of the coiled-coil motif on the rate of liposome fusion was studied, by varying the number of heptad repeats. We found that an increased coiled-coil stability of complementary peptides translates into increased rates of membrane fusion of liposomes.

Graphical abstract: Controlling the rate of coiled coil driven membrane fusion

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Article information

DOI
https://doi.org/10.1039/C3CC38926J
Article type
Communication
Submitted
13 Dec 2012
Accepted
08 Mar 2013
First published
13 Mar 2013

Chem. Commun., 2013,49, 3649-3651

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Controlling the rate of coiled coil driven membrane fusion

T. Zheng, J. Voskuhl, F. Versluis, H. R. Zope, I. Tomatsu, H. R. Marsden and A. Kros, Chem. Commun., 2013, 49, 3649 DOI: 10.1039/C3CC38926J

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