Issue 26, 2013
From the journal:

Chemical Communications

Highly sensitive detection of telomerase based on a DNAzyme strategy†

Tian Tian,‡a   Shuang Peng,‡a   Heng Xiao,a   Xiaoe Zhang,a   Shan Guo,a   Shaoru Wang,*a   Xiang Zhou,*ab   Songmei Liuc  and  Xin Zhouc  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: xzhou@whu.edu.cn, srwang@whu.edu.cn
Fax: +86-27-68756663
Tel: +86-27-68756663

b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China

c Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China

Abstract

The present study demonstrated a highly sensitive strategy for measuring telomerase activity in cell extracts. Furthermore, we applied the new strategy for in situ detection of telomerase at the cellular level in cancer cells, together with a normal cell as the negative control.

Graphical abstract: Highly sensitive detection of telomerase based on a DNAzyme strategy

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Article information

DOI
https://doi.org/10.1039/C3CC38818B
Article type
Communication
Submitted
09 Dec 2012
Accepted
10 Feb 2013
First published
11 Feb 2013

Chem. Commun., 2013,49, 2652-2654

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Highly sensitive detection of telomerase based on a DNAzyme strategy

T. Tian, S. Peng, H. Xiao, X. Zhang, S. Guo, S. Wang, X. Zhou, S. Liu and X. Zhou, Chem. Commun., 2013, 49, 2652 DOI: 10.1039/C3CC38818B

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