Issue 7, 2013

Indion 860 catalyzed cascade reaction: a greener approach to functionalized cyclohexanones and their novel analogues

Abstract

An Indion 860 mediated cascade reaction of β-ketoester or 1,3-diketone with alkyl/aryl/heteroaryl aldehydes afforded functionalized cyclohexanones in the open air. The catalyst can be recovered and recycled. Combining this methodology with other reactions in the same pot afforded diversity based novel molecules. Some of the synthesized compounds showed inhibition of PDE4 in vitro.

Graphical abstract: Indion 860 catalyzed cascade reaction: a greener approach to functionalized cyclohexanones and their novel analogues

Supplementary files

Article information

Article type
Communication
Submitted
05 Oct 2012
Accepted
18 Dec 2012
First published
20 Dec 2012

RSC Adv., 2013,3, 2207-2210

Indion 860 catalyzed cascade reaction: a greener approach to functionalized cyclohexanones and their novel analogues

T. Bhaskar Kumar, G. Dhananjaya, Ch. Sumanth, S. Vaishaly, G. Botre, M. S. Rao, K. B. C. Sekhar, K. S. Kumar and M. Pal, RSC Adv., 2013, 3, 2207 DOI: 10.1039/C2RA23039A

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