Issue 28, 2012
From the journal:

Organic & Biomolecular Chemistry

A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution†

Lu Wang,‡a   Jiefu Jin,‡b   Xishan Chen,a   Hai-Hua Fan,c   Billy King Fai Li,c   Kok-Wai Cheah,c   Ning Ding,a   Shenghong Ju,*d   Wing-Tak Wong*e  and  Cong Li*a  

* Corresponding authors

a Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University, Shanghai 201203, China
E-mail: congli@fudan.edu.cn
Fax: +86 21 5198 0100
Tel: +86 21 5198 0100

b Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong

c Centre of Advanced Luminescence Materials, Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China

d Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China
E-mail: jsh0836@hotmail.com
Fax: +86 25 8327 2121
Tel: +86 25 8331 1083

e Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Shenzhen Research Institute, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong
E-mail: bcwtwong@polyu.edu.hk
Fax: +852 2364 9932
Tel: +852 3440 8789

Abstract

Optical imaging provides an indispensable way to locate tumors in their early stages with high sensitivity and signal to background ratio. A heptamethine cyanine based fluorophore that emits both single photon near-infrared fluorescence and two-photon deep red fluorescence under physiological conditions was developed. Linear and nonlinear photophysical properties of this fluorophore were investigated and it demonstrated the capability to label lysosomes in cancer cells. The advantages of this fluorophore, including tolerable cytotoxicity, high fluorescence quantum yield, and the ability to emit both near-infrared single photon fluorescence and deep red two photon fluorescence in aqueous solution, give it potential to be used in intra-operatively optical image-guided tumor excision followed by two-photon fluorescence microscopy biopsy analysis after a single administration.

Graphical abstract: A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution

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Article information

DOI
https://doi.org/10.1039/C2OB25619C
Article type
Paper
Submitted
26 Mar 2012
Accepted
30 May 2012
First published
01 Jun 2012

Org. Biomol. Chem., 2012,10, 5366-5370

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A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution

L. Wang, J. Jin, X. Chen, H. Fan, B. K. F. Li, K. Cheah, N. Ding, S. Ju, W. Wong and C. Li, Org. Biomol. Chem., 2012, 10, 5366 DOI: 10.1039/C2OB25619C

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