Lanthanide ion-doped GdPO4 nanorods with dual-modal bio-optical and magnetic resonance imaging properties

Wenlu Ren; Gan Tian; Liangjun Zhou; Wenyan Yin; Liang Yan; Shan Jin; Yan Zu; Shoujian Li; Zhanjun Gu; Yuliang Zhao

doi:10.1039/C2NR30683B

Lanthanide ion-doped GdPO₄nanorods with dual-modal bio-optical and magnetic resonance imaging properties

Wenlu Ren,^a Gan Tian,^ac Liangjun Zhou,^ad Wenyan Yin,^a Liang Yan,^a Shan Jin,^ad Yan Zu,^a Shoujian Li,^c Zhanjun Gu*^a and Yuliang Zhao*^ab

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* Corresponding authors

^a Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China
E-mail: zjgu@ ihep.ac.cn, zhaoyuliang@ihep.ac.cn

^b Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, P. R. China

^c College of Chemistry, Sichuan University, Chengdu, P. R. China

^d College of Materials Science and Opto-Electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing, P. R. China

Abstract

Here, dual-modal bioprobes for combined optical and magnetic resonance (MR) imaging are reported. Gadolinium orthophosphate (GdPO₄) nanorods co-doped with light-emitting lanthanide ions have been successfully prepared through a hydrothermal method. An efficient downconversion luminescence from Ce/Tb or Eu doped GdPO₄ nanorods and upconversion luminescence from Yb/Er co-doped GdPO₄ nanorods are observed, respectively, which offers the optical modality for the nanoprobes. Notably, we first report the upconversion phenomenon based on the GdPO₄ matrix under 980 nm near infrared irradiation. The possibility of using these nanoprobes with downconversion and upconversion luminescent emissions for optical cell imaging is also demonstrated. Furthermore, these Gd³⁺-containing nanophosphors show good positive signal-enhancement ability when performed under a 4.7 T MR imaging scanner, indicating they have potential as T₁ MR imaging contrast agents. Thus, nanoprobes based on GdPO₄ nanophosphors are shown to provide the dual modality of optical and MR imaging.

Nanoscale

Lanthanide ion-doped GdPO₄nanorods with dual-modal bio-optical and magnetic resonance imaging properties

Abstract

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Lanthanide ion-doped GdPO₄ nanorods with dual-modal bio-optical and magnetic resonance imaging properties

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