Issue 7, 2012
From the journal:

Molecular BioSystems

More than just tails: intrinsic disorder in histoneproteins

Zhenling Peng,a   Marcin J. Mizianty,a   Bin Xue,b   Lukasz Kurgana  and  Vladimir N. Uversky*bc  

* Corresponding authors

a Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Canada
E-mail: zhenling@ualberta.ca, mizianty@ualberta.ca, lkurgan@ece.ualberta.ca

b Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, USA
E-mail: vuversky@health.usf.edu, bxue@health.usf.edu
Fax: +1-317-278-9217
Tel: +1-317-278-6448

c Institute for Biological Instrumentation, Russian Academy of Sciences, 12901 Bruce B. Downs Blvd. MDC07, 142290 Pushchino, Moscow Region, Russia

Abstract

Many biologically active proteins are disordered as a whole, or contain long disordered regions. These intrinsically disordered proteins/regions are very common in nature, abundantly found in all organisms, where they carry out important biological functions. The functions of these proteins complement the functional repertoire of “normal” ordered proteins, and many protein functional classes are heavily dependent on intrinsic disorder. Among these disorder-centric functions are interactions with nucleic acids and protein complex assembly. In this study, we present the results of comprehensive bioinformatics analyses of the abundance and roles of intrinsic disorder in 2007 histones from 746 species. We show that all the members of the histone family are intrinsically disordered proteins. Furthermore, intrinsic disorder is not only abundant in histones, but is absolutely necessary for various histone functions, starting from heterodimerization to formation of higher order oligomers, to interactions with DNA and other proteins, and to posttranslational modifications.

Graphical abstract: More than just tails: intrinsic disorder in histone proteins

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Article information

DOI
https://doi.org/10.1039/C2MB25102G
Article type
Paper
Submitted
17 Mar 2012
Accepted
07 Apr 2012
First published
12 Apr 2012

Mol. BioSyst., 2012,8, 1886-1901

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More than just tails: intrinsic disorder in histone proteins

Z. Peng, M. J. Mizianty, B. Xue, L. Kurgan and V. N. Uversky, Mol. BioSyst., 2012, 8, 1886 DOI: 10.1039/C2MB25102G

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