Issue 21, 2012
From the journal:

Dalton Transactions

Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages†

Anne-Sophie Bernard,‡abc   Claire Giroud,‡abc   H. Y. Vincent Ching,abc   Anne Meunier,abd   Vinita Ambike,e   Christian Amatore,*abd   Manon Guille Collignon,abd   Frédéric Lemaîtreabd  and  Clotilde Policar*abc  

* Corresponding authors

a Ecole Normale Supérieure, Département de chimie, 24, rue Lhomond, 75005 Paris, France
E-mail: clotilde.policar@ens.fr
Fax: +33-144323858

b Université Pierre et Marie Curie Paris 6, 4, Place Jussieu, 75005 Paris, France

c CNRS, UMR7203,

d CNRS, UMR8640,

e Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud 11, 91405 Orsay, France

Abstract

SOD-mimics are small complexes that reproduce the activity of superoxide dismutases, natural proteins that catalytically dismutate the superoxide anion. Activated macrophages, which produce ROS and RNS fluxes, constitute a relevant model to challenge antioxidant activity in a cellular context and were used to test a Mn-complex which was shown to efficiently alter the flow of O2−, ONOO− and H2O2.

Graphical abstract: Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages

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Article information

DOI
https://doi.org/10.1039/C2DT12479C
Article type
Communication
Submitted
23 Dec 2011
Accepted
16 Feb 2012
First published
12 Mar 2012

Dalton Trans., 2012,41, 6399-6403

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Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages

A. Bernard, C. Giroud, H. Y. V. Ching, A. Meunier, V. Ambike, C. Amatore, M. G. Collignon, F. Lemaître and C. Policar, Dalton Trans., 2012, 41, 6399 DOI: 10.1039/C2DT12479C

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