Issue 16, 2012
From the journal:

CrystEngComm

Mechanochemical synthesis of pyrazine:dicarboxylic acid cocrystals and a study of dissociation by quantitative phase analysis†

Mihails Arhangelskis,a   Gareth O. Lloyd*a  and  William Jones*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW
E-mail: William Jones: wj10@cam.ac.uk, Gareth O. Lloyd: gol20@cam.ac.uk

Abstract

Cocrystals of pyrazine with dicarboxylic acids were synthesised by mechanochemical methods. Crystal structure determination was performed by single crystal and powder X-ray diffraction (PXRD). The cocrystals consist of infinite 1D hydrogen-bonded chains exploiting the familiar pyridine-carboxylic acid synthon. The kinetics of dissociation of the pyrazine:phthalic acid cocrystal was studied at non-ambient conditions using PXRD and quantitative Rietveld phase analysis. We show that the dissociation process is both temperature and humidity dependent providing useful information about a possible dissociation mechanism.

Graphical abstract: Mechanochemical synthesis of pyrazine:dicarboxylic acid cocrystals and a study of dissociation by quantitative phase analysis

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Article information

DOI
https://doi.org/10.1039/C2CE25121C
Article type
Paper
Submitted
26 Jan 2012
Accepted
14 May 2012
First published
15 May 2012

CrystEngComm, 2012,14, 5203-5208

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Mechanochemical synthesis of pyrazine:dicarboxylic acid cocrystals and a study of dissociation by quantitative phase analysis

M. Arhangelskis, G. O. Lloyd and W. Jones, CrystEngComm, 2012, 14, 5203 DOI: 10.1039/C2CE25121C

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