Issue 4, 2013
From the journal:

Chemical Communications

Detection of single-nucleotide polymorphisms based on the formation of an electron-transfer impeding layer on an electrode surface

Zhiqiang Gao,*a   Wei Shen,a   Huimin Denga  and  Yuqian Rena  

* Corresponding authors

a Department of Chemistry, National University of Singapore, Singapore
E-mail: chmgaoz@nus.edu.sg
Fax: +65 6779-1691
Tel: +65 6516-3887

Abstract

An electrochemical biosensor utilizing the electron-transfer impeding (insulating) power of a conducting polymer for label-free genotyping single-nucleotide polymorphisms is proposed. Excellent selectivity and sensitivity are accomplished through the engagement of a nuclease clean-up step and a cumulative signal generation/amplification process, respectively.

Graphical abstract: Detection of single-nucleotide polymorphisms based on the formation of an electron-transfer impeding layer on an electrode surface

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Article information

DOI
https://doi.org/10.1039/C2CC37450A
Article type
Communication
Submitted
12 Oct 2012
Accepted
13 Nov 2012
First published
27 Nov 2012

Chem. Commun., 2013,49, 370-372

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Detection of single-nucleotide polymorphisms based on the formation of an electron-transfer impeding layer on an electrode surface

Z. Gao, W. Shen, H. Deng and Y. Ren, Chem. Commun., 2013, 49, 370 DOI: 10.1039/C2CC37450A

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