Issue 6, 2013
From the journal:

Chemical Communications

Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites†

Ken Cham-Fai Leung,*ab   Chun-Pong Chak,b   Siu-Fung Lee,b   Josie M. Y. Lai,c   Xiao-Ming Zhu,d   Yi-Xiang J. Wang,d   Kathy W. Y. Shamc  and  Christopher H. K. Cheng*c  

* Corresponding authors

a Institute of Creativity and Department of Chemistry, The Hong Kong Baptist University, Kowloon, Hong Kong SAR, P. R. China
E-mail: cfleung@hkbu.edu.hk
Tel: +852 3411 2319

b Institute of Molecular Functional Materials and Department of Chemistry, The Chinese University of Hong Kong, NT, Shatin, Hong Kong SAR, P. R. China

c School of Biomedical Sciences, The Chinese University of Hong Kong, NT, Shatin, Hong Kong SAR, P. R. China

d Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, NT, Shatin, Hong Kong SAR, P. R. China

Abstract

Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

Graphical abstract: Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

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Article information

DOI
https://doi.org/10.1039/C2CC36663K
Article type
Communication
Submitted
13 Sep 2012
Accepted
05 Nov 2012
First published
05 Nov 2012

Chem. Commun., 2013,49, 549-551

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Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

K. C. Leung, C. Chak, S. Lee, J. M. Y. Lai, X. Zhu, Y. J. Wang, K. W. Y. Sham and C. H. K. Cheng, Chem. Commun., 2013, 49, 549 DOI: 10.1039/C2CC36663K

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