Issue 24, 2012

A split ligand for lanthanide binding: facile evaluation of dimerizing proteins

Abstract

Luminescence of lanthanides is attractive for biological applications due to its long lifetime and sharp emission profiles. We describe the split display of a lanthanide binding ligand that allows facile evaluation of dimerizing proteins. The split lanthanide ligand is cysteine reactive, and therefore should be readily applicable to a variety of protein systems.

Graphical abstract: A split ligand for lanthanide binding: facile evaluation of dimerizing proteins

Supplementary files

Article information

Article type
Communication
Submitted
17 Dec 2011
Accepted
27 Jan 2012
First published
30 Jan 2012

Chem. Commun., 2012,48, 2997-2999

A split ligand for lanthanide binding: facile evaluation of dimerizing proteins

Y. Zhao and J. Gao, Chem. Commun., 2012, 48, 2997 DOI: 10.1039/C2CC17891E

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