Issue 7, 2012
From the journal:

Analytical Methods

Determination of eight tobacco alkaloids in flue-cured tobacco samples by gas chromatography with nitrogenchemiluminescence detection (NCD)

Kai Cai,a   Zhangmin Xiang,a   Jie Zhang,a   Shuping Zhou,a   Yonggang Feng*a  and  Zhaoliang Geng*a  

* Corresponding authors

a Analysis and Testing Center, Guizhou Tobacco Research Institute, Guiyang, Guizhou, China
E-mail: gyfyg@vip.sina.com, Zhaolianggeng@gmail.com
Tel: +86-851-4117027

Abstract

A reliable, sensitive and rapid method for determination of eight alkaloids in flue-cured tobacco by dual-column-dual-detector gas chromatography with nitrogen chemiluminescence detection (GC-NCD) has been established. At first, the extraction effects of several factors such as solid to liquid ratio, extraction time, sodium hydroxide solution volume and sodium hydroxide solution mass fraction on the extraction efficiency were simultaneously investigated using an orthogonal array design (OAD). Then, the NCD was compared to other detectors and showed some unique advantages. The analytical method met the strict quantitative requirement by optimizing chromatographic conditions and using dual-column confirmation. Finally, the performance of the proposed method was tested for the extraction and determination of the eight alkaloids in flue-cured tobacco and satisfactory results were achieved.

Graphical abstract: Determination of eight tobacco alkaloids in flue-cured tobacco samples by gas chromatography with nitrogen chemiluminescence detection (NCD)

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Article information

DOI
https://doi.org/10.1039/C2AY25067E
Article type
Paper
Submitted
18 Jan 2012
Accepted
12 Apr 2012
First published
12 Apr 2012

Anal. Methods, 2012,4, 2095-2100

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Determination of eight tobacco alkaloids in flue-cured tobacco samples by gas chromatography with nitrogen chemiluminescence detection (NCD)

K. Cai, Z. Xiang, J. Zhang, S. Zhou, Y. Feng and Z. Geng, Anal. Methods, 2012, 4, 2095 DOI: 10.1039/C2AY25067E

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