Issue 1, 2012

SERS assisted ultra-fast peptidic screening: a new tool for drug discovery

Abstract

Herein we present a direct label-free ultra-fast method for the identification and classification of the active members of a combinatorial library directly on the solid support used for their synthesis. The method is based on the appropriate functionalization of polyethylene glycol grafted polystyrene (TentaGel®) microbeads with Au@Ag nanoparticles, the use of these materials directly as solid-phase supports for the synthesis of combinatorial libraries of peptides and the subsequent SERS analysis for identification of each peptide on each bead.

Graphical abstract: SERS assisted ultra-fast peptidic screening: a new tool for drug discovery

Supplementary files

Article information

Article type
Communication
Submitted
13 Sep 2011
Accepted
04 Oct 2011
First published
09 Nov 2011

Nanoscale, 2012,4, 113-116

SERS assisted ultra-fast peptidic screening: a new tool for drug discovery

R. Pérez-Pineiro, M. A. Correa-Duarte, V. Salgueirino and R. A. Alvarez-Puebla, Nanoscale, 2012, 4, 113 DOI: 10.1039/C1NR11293G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements