Issue 7, 2011
From the journal:

MedChemComm

Carbocyclic 5′-nor “reverse” fleximers. Design, synthesis, and preliminary biological activity†

Sarah C. Zimmermann,a   Joshua M. Sadler,a   Graciela Andrei,b   Robert Snoeck,b   Jan Balzarinib  and  Katherine L. Seley-Radtke*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD, USA
E-mail: kseley@umbc.edu
Fax: +1-410-455-2608
Tel: +1-410-455-8684

b Rega Institute for Medical Research, K.U.Leuven, Minderbroedersstraat 10, Leuven, Belgium

Abstract

A series of 5′-nor carbocyclic “reverse” flexible nucleosides or “fleximers” have been designed wherein the nucleobase scaffold resembles a “split” purine as well as a substituted pyrimidine. This modification was employed to explore recognition by both purine and pyrimidine metabolizing enzymes. The synthesis of the carbocyclic fleximers and the results of their preliminary biological screening are described herein.

Graphical abstract: Carbocyclic 5′-nor “reverse” fleximers. Design, synthesis, and preliminary biological activity

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Article information

DOI
https://doi.org/10.1039/C1MD00094B
Article type
Concise Article
Submitted
31 Mar 2011
Accepted
25 Apr 2011
First published
19 May 2011

Med. Chem. Commun., 2011,2, 650-654

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Carbocyclic 5′-nor “reverse” fleximers. Design, synthesis, and preliminary biological activity

S. C. Zimmermann, J. M. Sadler, G. Andrei, R. Snoeck, J. Balzarini and K. L. Seley-Radtke, Med. Chem. Commun., 2011, 2, 650 DOI: 10.1039/C1MD00094B

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