Elastomeric nanocomposites as cell delivery vehicles and cardiac support devices

Qizhi Chen; Liyu Jin; Wayne D Cook; Dirk Mohn; Ebba L. Lagerqvist; David A. Elliott; John M. Haynes; Nicholas Boyd; Wendelin J. Stark; Colin W. Pouton; Edouard G. Stanley; Andrew G. Elefanty

doi:10.1039/C0SM00213E

Elastomeric nanocomposites as cell delivery vehicles and cardiac support devices†

Qizhi Chen,*^ab Liyu Jin,^a Wayne D Cook,^a Dirk Mohn,^c Ebba L. Lagerqvist,^d David A. Elliott,^e John M. Haynes,^d Nicholas Boyd,^a Wendelin J. Stark,^c Colin W. Pouton,^d Edouard G. Stanley^e and Andrew G. Elefanty^e

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* Corresponding authors

^a Department of Materials Engineering, Monash University, Clayton, Victoria, Australia
E-mail: qizhi.chen@monash.edu

^b Division of Bioengineering, Monash University, Clayton, Victoria, Australia

^c ETH, Inst Chem & Bioengn, Dept Chem & Appl Biosci, Zurich, Switzerland

^d Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

^e Monash Immunology & Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia

Abstract

A new family of elastomeric nanocomposites has been developed from a soft elastomer poly(glycerol sebacate, PGS) and nanoparticles of Bioglass^®. The new nanocomposites have been characterised in terms of materials science and evaluated for their potential clinical applications as cell delivery vehicles and cardiac support devices in the heart patch strategy. The addition of alkaline Bioglass^® effectively counteracts the acidity caused by the degradation of PGS without severely compromising the compliance of PGS. As a result, the newly developed PGS–nanoBioglass (<5 wt%) composites have a greatly improved biocompatibility, compared to PGS, and remain mechanically compatible with heart muscle. The interaction between PGS and Bioglass^® and the reinforcement of the PGS polymer network by the nanoBioglass^® particles have also been explored in depth.

Soft Matter

Elastomeric nanocomposites as cell delivery vehicles and cardiac support devices†

Abstract

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Elastomeric nanocomposites as cell delivery vehicles and cardiac support devices

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