Issue 8, 2011
From the journal:

Organic & Biomolecular Chemistry

Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling†

Samuel Reyes,a   Robert W. Huigens III,a   Zhaoming Su,a   Michel L. Simona  and  Christian Melander*a  

* Corresponding authors

a North Carolina State University, Department of Chemistry, Raleigh, North Carolina, USA
E-mail: Christian_Melander@ncsu.edu

Abstract

A pilot library of 2-aminoimidazole triazoles (2-AITs) was synthesized and assayed against Acinetobacter baumannii and methicillin-resistant Staphylococus aureus (MRSA). Results from these studies show that these new derivatives have improved biofilm dispersal activities as well as antibacterial properties against A. baumannii. With MRSA biofilms they are found to possess biofilm inhibition capabilities at low micromolar concentrations.

Graphical abstract: Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling

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Article information

DOI
https://doi.org/10.1039/C0OB00925C
Article type
Paper
Submitted
23 Oct 2010
Accepted
03 Feb 2011
First published
10 Mar 2011

Org. Biomol. Chem., 2011,9, 3041-3049

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Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling

S. Reyes, R. W. Huigens III, Z. Su, M. L. Simon and C. Melander, Org. Biomol. Chem., 2011, 9, 3041 DOI: 10.1039/C0OB00925C

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