Issue 3, 2011
From the journal:

Organic & Biomolecular Chemistry

Enhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone†

Nagendra K. Sharma*a  and  Krishna N. Ganeshb  

* Corresponding authors

a National Institute of Science Education and Research (NISER) IOP Campus, P.O.:Sainik School, Bhubaneswar, Orissa, India
E-mail: nagendra@niser.ac.in
Tel: 91-674-230-4130, 91-674-230-4094

b Indian Institute of Science Education and Research (IISER)-Pune 900, NCL Innovation Park, JC Bose Fellow, Division of Organic Chemistry, National Chemical Laboratory, Dr Homi Bhabha Road Pune, India
E-mail: kn.ganesh@iiserpune.ac.in
Fax: +91 20 2589 9790
Tel: +91 20 2590 8000

Abstract

Nucleic (DNA) acids having contiguous stretch of G sequence form quadruplex structure, which is very critical to control cell division. Recently the existence of G-quadruplex in RNA is also reported in presence of monovalent metal ion. PNA is a promising DNA analogue which binds strongly to DNA to form PNA : DNA duplex or PNA2 : DNA triplex. PNA also forms quadruplexes such G-quadruplex and i-motif in G and C-rich sequences respectively. aep-PNA containing a prolyl ring is one of several PNA analogues that provide rigidity and chirality in backbone and has binding affinity to natural DNA which is higher than that of PNA. Here we examine the ability of aep-PNA-G to form a quadruplex by UV, CD and mass spectroscopic techniques.

Graphical abstract: Enhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone

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Article information

DOI
https://doi.org/10.1039/C0OB00528B
Article type
Paper
Submitted
02 Aug 2010
Accepted
16 Sep 2010
First published
15 Nov 2010

Org. Biomol. Chem., 2011,9, 725-729

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Enhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone

N. K. Sharma and K. N. Ganesh, Org. Biomol. Chem., 2011, 9, 725 DOI: 10.1039/C0OB00528B

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