Issue 13, 2011

“Bioelectronic super-taster” device based on taste receptor-carbon nanotube hybrid structures

Abstract

We have developed a method to monitor the activities of human taste receptor protein in lipid membrane using carbon nanotube transistors, enabling a “bioelectronic super-taster (BST)”, a taste sensor with human-tongue-like selectivity. In this work, human bitter taste receptor protein expressed in E. coli was immobilized on a single-walled carbon nanotube field effect transistor (swCNT-FET) with the lipid membrane. Then, the protein binding activity was monitored using the underlying swCNT-FET, leading to the operation as a BST device. The fabricated BST device could detect bitter tastants at 100 fM concentrations and distinguish between bitter and non-bitter tastants with similar chemical structures just like a human tongue. Furthermore, this strategy was utilized to differentiate the responses of taster or non-taster types of the bitter taste receptor proteins.

Graphical abstract: “Bioelectronic super-taster” device based on taste receptor-carbon nanotube hybrid structures

Supplementary files

Article information

Article type
Paper
Submitted
01 Dec 2010
Accepted
24 Mar 2011
First published
05 May 2011

Lab Chip, 2011,11, 2262-2267

“Bioelectronic super-taster” device based on taste receptor-carbon nanotube hybrid structures

T. H. Kim, H. S. Song, H. J. Jin, S. H. Lee, S. Namgung, U. Kim, T. H. Park and S. Hong, Lab Chip, 2011, 11, 2262 DOI: 10.1039/C0LC00648C

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