Issue 2, 2011
From the journal:

Food & Function

Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

Min-Hsiung Pan,*a   Yi-Siou Chiou,ab   Yin-Jen Wang,b   Chi-Tang Hoc  and  Jen-Kun Lin*d  

* Corresponding authors

a Department of Seafood Science, National Kaohsiung Marine University, No.142, Haijhuan Rd., Nanzih District, Kaohsiung, Taiwan
E-mail: mhpan@mail.nkmu.edu.tw
Fax: (+886)-7-361-1261
Tel: (+886)-7-361-7141 ext. 3623

b Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan

c Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA

d Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-ai Road, Taipei, Taiwan
E-mail: jklin@ha.mc.ntu.edu.tw
Fax: (+886)-2-2391-8944
Tel: (+886)-2-2356-2213

Abstract

The consumption of green tea has long been associated with a reduced risk of cancer development. (−)-Epicatechin-3-gallate (ECG) or (−)-epigallocatechin-3-gallate (EGCG) are the major antioxidative polyphenolic compounds of green tea. They have been shown to exert growth-inhibitory potential of various cancer cells in culture and antitumor activity in vivo models. ECG or EGCG could interact with various molecules like proteins, transcription factors, and enzymes, which block multiple stages of carcinogenesis via regulating intracellular signaling transduction pathways. Moreover, ECG and EGCG possess pharmacological and physiological properties including induction of phase II enzymes, mediation of anti-inflammation response, regulation of cell proliferation and apoptosis effects and prevention of tumor angiogenesis, invasion and metastasis. Numerous review articles have been focused on EGCG, however none have been focused on ECG despite many studies supporting the cancer preventive potential of ECG. To develop ECG as an anticarcinogenic agent, more clear understanding of the cell signaling pathways and the molecular targets responsible for chemopreventive and chemotherapeutic effects are needed. This review summarizes recent research on the ECG-induced cellular signal transduction events which implicate in cancer management.

Graphical abstract: Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

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Article information

DOI
https://doi.org/10.1039/C0FO00174K
Article type
Review Article
Submitted
06 Dec 2010
Accepted
22 Dec 2010
First published
18 Jan 2011

Food Funct., 2011,2, 101-110

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Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate

M. Pan, Y. Chiou, Y. Wang, C. Ho and J. Lin, Food Funct., 2011, 2, 101 DOI: 10.1039/C0FO00174K

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