Issue 1, 2011
From the journal:

Dalton Transactions

Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]

Luca Ronconi†b  and  Peter J. Sadler*a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, UK
E-mail: P.J.Sadler@warwick.ac.uk
Fax: (+44)-24-7652-3819
Tel: (+44)-24-7652-3818

b School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh, UK

Abstract

The photodecomposition of the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2] in acidic aqueous solution, as well as in phosphate-buffered saline (PBS), induced by UVA light (centred at λ = 365 nm) has been studied by multinuclear NMR spectroscopy. We show that the photoreaction pathway in PBS, which involves azide release, differs from that in acidic aqueous conditions, under which N2 is a major product. In both cases, a number of trans-{N–Pt(II/IV)–NH3} species were also observed as photoproducts, as well as the evolution of O2 and release of free ammonia with a subsequent increase in pH. The results from this study illustrate that photoinduced reactions of Pt(IV)-diazido derivatives can lead to novel reaction pathways, and therefore potentially to new cytotoxic mechanisms in cancer cells.

Graphical abstract: Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]

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Article information

DOI
https://doi.org/10.1039/C0DT00546K
Article type
Paper
Submitted
25 May 2010
Accepted
11 Oct 2010
First published
12 Nov 2010

Dalton Trans., 2011,40, 262-268

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Photoreaction pathways for the anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)2]

L. Ronconi and P. J. Sadler, Dalton Trans., 2011, 40, 262 DOI: 10.1039/C0DT00546K

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