Issue 12, 2011
From the journal:

Chemical Communications

In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines†

Manuela Tosin,‡*ab   Yuliya Demydchuk,a   James S. Parascandolo,a   Covadonga Blasco Per,b   Finian J. Leeperb  and  Peter F. Leadlay*a  

* Corresponding authors

a Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
E-mail: pfl10@mole.bio.cam.ac.uk
Fax: +44 1223 766002
Tel: +44 1223 336710

b University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

Abstract

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.

Graphical abstract: In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

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Article information

DOI
https://doi.org/10.1039/C0CC05077F
Article type
Communication
Submitted
21 Nov 2010
Accepted
24 Jan 2011
First published
08 Feb 2011

Chem. Commun., 2011,47, 3460-3462

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In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

M. Tosin, Y. Demydchuk, J. S. Parascandolo, C. Blasco Per, F. J. Leeper and P. F. Leadlay, Chem. Commun., 2011, 47, 3460 DOI: 10.1039/C0CC05077F

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