Issue 43, 2010
From the journal:

Chemical Communications

A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy†

Gegen Tana,a   Shingo Kitada,a   Shuji Fujita,b   Yohei Okada,a   Shokaku Kima  and  Kazuhiro Chiba*a  

* Corresponding authors

a Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
E-mail: chiba@cc.tuat.ac.jp
Fax: (+81)-42-360-7167
Tel: (+81)-42-367-5667

b JITSUBO Co. Ltd., 2-24-16 Naka-cho, Koganei, Tokyo 184-0012, Japan

Abstract

A simple acid-resistant hydrophobic tag, which can be removed rapidly in a single-step procedure after overall peptide synthesis, has been developed to accomplish practical solution-phase synthesis of a 15-mer antagonistic peptide of TNF-α (A-TNF-α). Hydrophobically tagged peptides can be separated as precipitates at each step by addition of a polar organic solvent.

Graphical abstract: A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy

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Article information

DOI
https://doi.org/10.1039/C0CC03090B
Article type
Communication
Submitted
06 Aug 2010
Accepted
07 Sep 2010
First published
30 Sep 2010

Chem. Commun., 2010,46, 8219-8221

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A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy

G. Tana, S. Kitada, S. Fujita, Y. Okada, S. Kim and K. Chiba, Chem. Commun., 2010, 46, 8219 DOI: 10.1039/C0CC03090B

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