Issue 12, 2010
From the journal:

Soft Matter

Salt-induced lipid transfer between colloidal supported lipid bilayers†

Eric L. Kendall,a   Emily Mills,a   Juewen Liu,c   Xingmao Jiang,d   C. Jeffrey Brinkerbd  and  Atul N. Parikh*a  

* Corresponding authors

a Departments of Chemical Engineering and Materials Science, and of Applied Science, University of California, Davis, CA, USA
E-mail: anparikh@ucdavis.edu

b Sandia National Laboratories, Albuquerque, NM, USA

c Department of Chemistry, University of Waterloo, Waterloo, ON, Canada

d Department of Chemical Engineering, University of New Mexico, Albuquerque, NM, USA

Abstract

We show that a coordinated interplay between mesoscale colloidal interactions and molecular-scale membrane perturbations affords a novel material platform to controllably recapitulate membrane interactions, such as during fusion and vesicle-based drug delivery. Specifically, a simple modulation of ionic strength is used to alter electrostatically determined colloidal interactions, producing conditions for pre-fusion contact between two independent colloidal and/or planar supported lipid bilayers. The same process also perturbs the membrane at the molecular level, reproducing conditions needed for subsequent fusion steps. We envisage that this platform will yield insights relevant to optimal design and implementation of lipid-coated inorganic constructs used for therapeutic drug delivery and sensing.

Graphical abstract: Salt-induced lipid transfer between colloidal supported lipid bilayers

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Article information

DOI
https://doi.org/10.1039/C001586E
Article type
Communication
Submitted
23 Jan 2010
Accepted
10 Mar 2010
First published
30 Mar 2010

Soft Matter, 2010,6, 2628-2632

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Salt-induced lipid transfer between colloidal supported lipid bilayers

E. L. Kendall, E. Mills, J. Liu, X. Jiang, C. J. Brinker and A. N. Parikh, Soft Matter, 2010, 6, 2628 DOI: 10.1039/C001586E

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