Issue 48, 2009
From the journal:

Chemical Communications

Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process†

Qian Cai,*a   Zhengqiu Li,b   Jiajia Wei,a   Chengyong Ha,b   Duanqing Peia  and  Ke Ding*a  

* Corresponding authors

a Key Laboratory of Regenerative Biology, Institute of Chemical Biology, Guangzhou Institute of Biomedicine, Health, Chinese Academy of Sciences, Guangzhou International Business Incubator D-10, Guangzhou Science Park, Guangzhou, China
E-mail: cai_qian@gibh.ac.cn, ding_ke@gibh.ac.cn
Fax: (+)86-20-32290606

b Key Laboratory of Cellulose and Lignocellulosics Chemistry, Guangzhou Institute of Chemistry, Chinese Academy of Sciences, China

Abstract

A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-subtrates under room temperature or mild conditions.

Graphical abstract: Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B918345K
Article type
Communication
Submitted
07 Sep 2009
Accepted
16 Oct 2009
First published
04 Nov 2009

Chem. Commun., 2009, 7581-7583

Permissions

Request permissions

Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

Q. Cai, Z. Li, J. Wei, C. Ha, D. Pei and K. Ding, Chem. Commun., 2009, 7581 DOI: 10.1039/B918345K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements