Issue 8, 2010
From the journal:

Chemical Society Reviews

3′,5′-Cyclic diguanylic acid: a small nucleotide that makes big impacts

Hongbin Yan*ab  and  Wangxue Chencd  

* Corresponding authors

a Department of Chemistry, Brock University, 500 Glenridge Ave., St. Catharines, Ontario, Canada
E-mail: tyan@brocku.ca
Fax: +1 905 6829020
Tel: +1 905 6885550 x 3545

b Centre for Biotechnology, Brock University, 500 Glenridge Ave., St. Catharines, Ontario, Canada

c Institute for Biological Sciences, National Research Council Canada, 100 Sussex Dr, Ottawa, Ontario, Canada
E-mail: wangxue.chen@nrc.gc.ca
Fax: +1 613 9529092
Tel: +1 613 9910924

d Department of Biological Sciences, Brock University, 500 Glenridge Ave., St. Catharines, Ontario, Canada

Abstract

3′,5′-Cyclic diguanylic acid (c-di-GMP) is a naturally occurring small cyclic dinucleotide found in bacteria. There has been a recent surge of interest in the two-component signalling networks involving this molecule. This tutorial review introduces the biosynthesis of c-di-GMP, particularly the conserved domain features involved in its enzymatic synthesis and degradation, cellular functions and phenotypes regulated by c-di-GMP through c-di-GMP-binding proteins. The chemical synthesis and structural studies of c-di-GMP are also summarized. Two potential applications of c-di-GMP, i.e. bacterial biofilm formation and immunostimulation, are surveyed. Recent observations on c-di-GMP-binding riboswitches are also introduced.

Graphical abstract: 3′,5′-Cyclic diguanylic acid: a small nucleotide that makes big impacts

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Article information

DOI
https://doi.org/10.1039/B914942M
Article type
Tutorial Review
Submitted
01 Feb 2010
First published
25 Jun 2010

Chem. Soc. Rev., 2010,39, 2914-2924

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3′,5′-Cyclic diguanylic acid: a small nucleotide that makes big impacts

H. Yan and W. Chen, Chem. Soc. Rev., 2010, 39, 2914 DOI: 10.1039/B914942M

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