Issue 4, 2010
From the journal:

Chemical Communications

Engineered transaminopeptidase, aminolysin-S for catalysis of peptide bond formation to give linear and cyclic dipeptides by one-pot reaction†

Hirokazu Usuki,a   Yoshiko Uesugi,ab   Jiro Arima,c   Yukihiro Yamamoto,a   Masaki Iwabuchia  and  Tadashi Hatanaka*a  

* Corresponding authors

a Research Institute for Biological Sciences (RIBS), Okayama, 7549-1 Kibichuo-cho, Kaga-gun, Okayama 716-1241, Japan
E-mail: hatanaka@bio-ribs.com
Fax: +81 866 56 9454
Tel: +81 866 56 9452

b Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan

c Department of Agricultural, Biological, and Environmental Sciences, Faculty of Agriculture Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan

Abstract

Aminopeptidase from Streptomyces thermocyaneoviolaceus NBRC14271 was engineered into transaminopeptidase and used to catalyze an aminolysis reaction to give linear and cyclic dipeptides from cost-effective substrates such as the ester derivatives of amino acids.

Graphical abstract: Engineered transaminopeptidase, aminolysin-S for catalysis of peptide bond formation to give linear and cyclic dipeptides by one-pot reaction

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Article information

DOI
https://doi.org/10.1039/B914320C
Article type
Communication
Submitted
16 Jul 2009
Accepted
17 Nov 2009
First published
04 Dec 2009

Chem. Commun., 2010,46, 580-582

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Engineered transaminopeptidase, aminolysin-S for catalysis of peptide bond formation to give linear and cyclic dipeptides by one-pot reaction

H. Usuki, Y. Uesugi, J. Arima, Y. Yamamoto, M. Iwabuchi and T. Hatanaka, Chem. Commun., 2010, 46, 580 DOI: 10.1039/B914320C

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