Issue 42, 2009
From the journal:

Dalton Transactions

Glucosamine conjugates bearing N,N,O-donors: potential imaging agents utilizing the [M(CO)3]+ core (M = Re, Tc)†

Meryn L. Bowen,a   Nathaniel C. Lim,ab   Charles B. Ewart,ab   Ripen Misri,c   Cara L. Ferreira,ab   Urs Häfeli,c   Michael J. Adam*b  and  Chris Orvig*a  

* Corresponding authors

a Medicinal Inorganic Chemistry Group, Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada
E-mail: orvig@chem.ubc.ca
Fax: +01 604 822 2847
Tel: +01 604 822 4449

b TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, Canada
E-mail: adam@triumf.ca

c Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada

Abstract

The design rationale, synthesis and radiolabeling evaluation of four glucosamine conjugated ligands for the [99mTc(CO)3]+ core is described. The capability to bind the tricarbonyl core is initially demonstrated using the cold surrogate [Re(CO)3]+. The four compounds are competent chelates in binding [99mTc(CO)3]+ as labeling studies show, with yields ranging from 79 to 96% and the resulting complexes showing stability in the presence of competing chelates for 24 h at 37 °C. The rhenium complexes were tested for hexokinase-catalysed phosphorylation, and the technetium complexes were tested for GLUT-1 mediated cell uptake - they showed a small amount of uptake but it was not glucose dependent, suggesting that it was not via the GLUT-1 transporters.

Graphical abstract: Glucosamine conjugates bearing N,N,O-donors: potential imaging agents utilizing the [M(CO)3]+ core (M = Re, Tc)

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B914310F
Article type
Paper
Submitted
16 Jul 2009
Accepted
04 Sep 2009
First published
25 Sep 2009

Dalton Trans., 2009, 9216-9227

Permissions

Request permissions

Glucosamine conjugates bearing N,N,O-donors: potential imaging agents utilizing the [M(CO)3]+ core (M = Re, Tc)

M. L. Bowen, N. C. Lim, C. B. Ewart, R. Misri, C. L. Ferreira, U. Häfeli, M. J. Adam and C. Orvig, Dalton Trans., 2009, 9216 DOI: 10.1039/B914310F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements