Issue 34, 2009
From the journal:

Chemical Communications

Silica nanoparticle supported lipid bilayers for gene delivery†

Juewen Liu,‡a   Alison Stace-Naughtona  and  C. Jeffrey Brinker*ab  

* Corresponding authors

a Center for Micro-Engineered Materials, University of New Mexico, Albuquerque, USA
E-mail: cjbrink@sandia.gov
Fax: +1 505-272-7336
Tel: +1 505-272-7629

b Departments of Chemical and Nuclear Engineering and Molecular Genetics and Microbiology, University of New Mexico, Sandia National Laboratories, Albuquerque, USA

Abstract

Silica nanoparticle supported cationic lipids can effectively bind plasmidDNAs and transfect mammalian cells with an efficiency that depends on both the particle size and lipid composition; here the gene delivery and expression process has been confirmed by confocal fluorescence microscopy.

Graphical abstract: Silica nanoparticle supported lipid bilayers for gene delivery

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Article information

DOI
https://doi.org/10.1039/B911472F
Article type
Communication
Submitted
11 Jun 2009
Accepted
10 Jul 2009
First published
28 Jul 2009

Chem. Commun., 2009, 5100-5102

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Silica nanoparticle supported lipid bilayers for gene delivery

J. Liu, A. Stace-Naughton and C. J. Brinker, Chem. Commun., 2009, 5100 DOI: 10.1039/B911472F

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