Issue 19, 2008
From the journal:

Organic & Biomolecular Chemistry

The effect of gas-phase reactions on the quantitation of cyclic hydrazone libraries by electrospray ionization (ESI) mass spectrometry†

Holly Schiltz,a   Mee-Kyung Chung,a   Stephen J. Leeb  and  Michel R. Gagné*a  

* Corresponding authors

a Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
E-mail: mgagne@unc.edu

b U.S. Army Research Office, P.O. Box 12211, Research Triangle Park, North Carolina
E-mail: Stephen.Lee2@us.army.mil

Abstract

Using mass spectrometry coupled with LC analysis we report evidence of diastereomer dependent fragmentation and oligomerization reactions in the ionization of acyl-hydrazone-based libraries of cyclic oligomers. These effects can significantly affect the accuracy of MS-based quantitations, but also provide a venue for examining ionization effects in dynamic combinatorial libraries (DCLs).

Graphical abstract: The effect of gas-phase reactions on the quantitation of cyclic hydrazone libraries by electrospray ionization (ESI) mass spectrometry

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Article information

DOI
https://doi.org/10.1039/B808490D
Article type
Paper
Submitted
21 May 2008
Accepted
03 Jul 2008
First published
06 Aug 2008

Org. Biomol. Chem., 2008,6, 3597-3600

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The effect of gas-phase reactions on the quantitation of cyclic hydrazone libraries by electrospray ionization (ESI) mass spectrometry

H. Schiltz, M. Chung, S. J. Lee and M. R. Gagné, Org. Biomol. Chem., 2008, 6, 3597 DOI: 10.1039/B808490D

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