Issue 10, 2008
From the journal:

Chemical Communications

Reagent-controlled domino synthesis of skeletally-diverse compound collections†

Herbert Waldmann,*ab   Marc Kühn,ab   Wei Liuab  and  Kamal Kumar*ab  

* Corresponding authors

a Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Straße 11, Germany

b Universität Dortmund, Fachbereich 3, Chemische Biologie, Otto-Hahn Straße 6, Germany
E-mail: Kamal.Kumar@mpi-dortmund.mpg.de, Herbert.Waldmann@mpi-dortmund.mpg.de
Fax: +49 231-133-2499

Abstract

An efficient reagent-controlled methodology for generating highly substituted diverse scaffolds from a common substrate has been developed; thus, treatment of a common precursor with different desilylating reagents, such as ammonium fluoride, caesium fluoride and PPTS, triggers different domino reaction sequences, yielding highly substituted pyridines, phenols and benzopyrans, respectively; the substituent patterns of these scaffolds provide further opportunities for library development.

Graphical abstract: Reagent-controlled domino synthesis of skeletally-diverse compound collections

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Article information

DOI
https://doi.org/10.1039/B717635J
Article type
Communication
Submitted
14 Nov 2007
Accepted
10 Dec 2007
First published
04 Jan 2008

Chem. Commun., 2008, 1211-1213

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Reagent-controlled domino synthesis of skeletally-diverse compound collections

H. Waldmann, M. Kühn, W. Liu and K. Kumar, Chem. Commun., 2008, 1211 DOI: 10.1039/B717635J

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