Issue 10, 2007
From the journal:

Analyst

Preparation and characterization of calibration standards for bone density determination by micro-computed tomography

Susanne Schweizer,*a   Bodo Hattendorf,b   Philipp Schneider,a   Beat Aeschlimann,b   Ludwig Gauckler,c   Ralph Müllera  and  Detlef Güntherb  

* Corresponding authors

a Institute for Biomedical Engineering, University and ETH Zürich, Switzerland
E-mail: schweizer@biomed.ee.ethz.ch

b Institute of Inorganic Chemistry, ETH Zürich, Switzerland

c Department of Materials, Nonmetallic Inorganic Materials, ETH Zürich, Switzerland

Abstract

Phantoms for the calibration of local bone mineral densities by micro-computed tomography (μCT), consisting of lithium tetraborate (Li2B4O7) with increasing concentrations of hydroxyapatite [HAp, Ca10(PO4)6(OH)2] have been prepared and characterized for homogeneity. Large-scale homogeneity and concentration of HAp in the phantom materials was determined using laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS), while homogeneity on the micrometer scale was assessed through μCT. A series of standards was prepared by fusion of pure HAp with Li2B4O7 in a concentration range between 0.12 and 0.74 g cm−3. Furthermore, pressed and sintered pellets of pure HAp were prepared to extend the calibration range towards densities of up to 3.05 g cm−3. A linear calibration curve was constructed using all individual standard materials and the slope of the curve was in good agreement with calculated absorption coefficients at the effective energy of the μCT scanner.

Graphical abstract: Preparation and characterization of calibration standards for bone density determination by micro-computed tomography

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Article information

DOI
https://doi.org/10.1039/B703220J
Article type
Paper
Submitted
02 Mar 2007
Accepted
23 Jul 2007
First published
07 Aug 2007

Analyst, 2007,132, 1040-1045

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Preparation and characterization of calibration standards for bone density determination by micro-computed tomography

S. Schweizer, B. Hattendorf, P. Schneider, B. Aeschlimann, L. Gauckler, R. Müller and D. Günther, Analyst, 2007, 132, 1040 DOI: 10.1039/B703220J

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