Physical organic chemistry studies utilizing gas-phase ion chemistry in the past year are summarized. The studies reported range from thermochemical studies, illustrated by the isomeric cyclohexane acidity study and the study of alkyl cation reactions with ozone, to mechanistic investigations that find solvation to have very little influence in the transition state of S_N2 reactions. Also included are groundbreaking structural studies exemplified in the generation and characterization of the first example of an open-shell doublet triradical, and the integration of previously autonomous techniques in an empirical study of the reaction of previously difficult to generate neutral organic intermediates with ions. Studies of biological and organometallic reagents are also surveyed, as well as advances in photoelectron spectroscopy.