Issue 16, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines

Zhanru Yu,a   Sonia Alesso,a   David Pears,*b   Paul A. Worthington,c   Richard W. A. Luked  and  Mark Bradley*a  

* Corresponding authors

a Department of Chemistry, University of Southampton, Southampton, UK

b Avecia, PO Box 42, Hexagon House, Blackley, Manchester, UK

c Syngenta, Jealott's Hill Research Station, Bracknell, Berkshire, UK

d AstraZeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, UK

Abstract

A ketoester resin was developed as the basis for a selective scavenger for primary amines in the presence of secondary amines. The utility of the scavenger was demonstrated with a range of reductive amination chemistries with both mono- and diamines. The resin's specificity is based on the removal of the primary amines via their enamines.

Graphical abstract: Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines

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Article information

DOI
https://doi.org/10.1039/B101395P
Article type
Paper
Submitted
13 Feb 2001
Accepted
22 Jun 2001
First published
27 Jul 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 1947-1952

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Ketoester methacrylate resin, secondary amine clean-up in the presence of primary amines

Z. Yu, S. Alesso, D. Pears, P. A. Worthington, R. W. A. Luke and M. Bradley, J. Chem. Soc., Perkin Trans. 1, 2001, 1947 DOI: 10.1039/B101395P

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