1  H and 13C nuclear magnetic resonance studies on X-537A (lasalocid-A)–calcium complexes: observation of a sandwich complex

Chitradurga K. Vishwanath; Kalpathy R. K. Easwaran

doi:10.1039/P29850000065

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

¹H and ¹³C nuclear magnetic resonance studies on X-537A (lasalocid-A)–calcium complexes: observation of a sandwich complex

Chitradurga K. Vishwanath and Kalpathy R. K. Easwaran

Abstract

Studies on the conformational and binding characteristics of the ionophoric antibiotic X-537A (lasalocid-A)–calcium ion complexes have been carried out in deuteriated acetonitrile (CD₃ CN) using proton and carbon-13 nuclear magnetic resonance (¹ H and ¹³C n.m.r.) spectroscopy. Detailed analysis of the salt-induced chemical shifts at various X-537A to calcium concentration ratios indicated that X-537A forms charged complexes with calcium with 2 : 1 and 1 : 1 stoicheiometries. The conformational model for the complex based on the n.m.r. data showed that the calcium ion is preferentially bound to one end of the molecule, which is binding to three oxygen atoms, the other end (the salicylic acid part) being relatively free. In the 2 : 1 (sandwich) complex, the calcium ion is sandwiched between two X-537A molecules with three oxygen atoms binding to it from each molecule.

Download options Please wait...

Article information

DOI: https://doi.org/10.1039/P29850000065
Article type: Paper

Download Citation

J. Chem. Soc., Perkin Trans. 2, 1985, 65-68

Permissions

Request permissions

¹ H and ¹³C nuclear magnetic resonance studies on X-537A (lasalocid-A)–calcium complexes: observation of a sandwich complex

C. K. Vishwanath and K. R. K. Easwaran, J. Chem. Soc., Perkin Trans. 2, 1985, 65 DOI: 10.1039/P29850000065

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Fetching data from CrossRef.
This may take some time to load.

Journal of the Chemical Society, Perkin Transactions 2