Issue 1, 1994
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

New synthetic applications of sialic acid aldolase, a useful catalyst for KDO synthesis. Relation between substrate conformation and enzyme stereoselectivity

Udo Kragl,   Astrid Gödde,   Christian Wandrey,   Nadège Lubin  and  Claudine Augé  

Abstract

In the sialic acid aldolase-catalysed addition of pyruvate with D-arabinose leading to a mixture of 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) and 4-epi-KDO (both in pyranose and furanose form), a high concentration of the acceptor D-arabinose have been found to increase the percentage of KDO up to 83%. KDO synthesis scaled up in the enzyme membrane reactor is reported. New condensation products obtained from L-xylose, L-allose, D-altrose and D-ribose as substrates are described as well. Kinetic parameters for the cleavage of KDO and 4-epi-KDO and the addition reaction between pyruvate and xylose and arabinose are given. Some apparent relation between enzyme stereoselectivity and conformation and stereochemistry at carbon C-3 of the substrate is discussed.

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/P19940000119
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1994, 119-124

Permissions

Request permissions

New synthetic applications of sialic acid aldolase, a useful catalyst for KDO synthesis. Relation between substrate conformation and enzyme stereoselectivity

U. Kragl, A. Gödde, C. Wandrey, N. Lubin and C. Augé, J. Chem. Soc., Perkin Trans. 1, 1994, 119 DOI: 10.1039/P19940000119

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements