Application of an intramolecular Michaelis–Arbusov reaction to the synthesis of nucleoside 3′-S,5′-O-cyclic phosphorothiolate triesters
Abstract
An intramolecular Michaelis–Arbusov reaction taking place between a 5′-phosphite and a 3′-S-disulfide can be used to prepare nucleoside 3′-S,5′-O-cyclic phosphorothiolate triesters.