Issue 13, 1992
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Solid-phase synthesis and characterization of O-dimannosylated heptadecapeptide analogues of human insulin-like growth factor 1 (IGF-1)

Anita M. Jansson,   Morten Meldal  and  Klaus Bock  

Abstract

N α -Fmoc-3-O-[Ac4-α-D-Manp-(1→2)-Ac3-α-D-Manp-1-]-Thr-OPfp, 7, and Nα-Fmoc-3-O-[Ac4-α-D-Manp-(1→2)-Ac3-α-D-Manp-1-]-Ser-OPfp, 8, were prepared and used as building blocks in automated continuous-flow solid-phase glycopeptide synthesis of two O-glycosylated heptadecapeptide analogues of human insulin-like growth factor 1. The corresponding non-glycosylated fragments were also prepared, and comparative NMR studies regarding the influence of the sugar moiety on the peptide backbone showed only limited effects due to glycosylation.

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Article information

DOI
https://doi.org/10.1039/P19920001699
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1992, 1699-1707

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Solid-phase synthesis and characterization of O-dimannosylated heptadecapeptide analogues of human insulin-like growth factor 1 (IGF-1)

A. M. Jansson, M. Meldal and K. Bock, J. Chem. Soc., Perkin Trans. 1, 1992, 1699 DOI: 10.1039/P19920001699

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