Issue 9, 1975
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Studies concerning the antibiotic actinonin. Part II. Total synthesis of actinonin and some structural analogues by the isomaleimide method

Nicholas H. Anderson,   W. David Ollis,   John E. Thorpe  and  A. David Ward  

Abstract

A general method for the synthesis of actinonin (I) and several structural analogues is described. L-Valyl-L-prolinol (III) and the isomaleimide (XIV) yield the intermediate (XVII), which gives actinonin (I) on hydrogenation. Corresponding routes yield compounds (XXV)(L-alanylpyrrolidine and DL-alanylpyrrolidine analogues), (XXVI)(L-valylpyrrolidine analogue), and (XXVII)(L-valyl-L-prolinol analogue), which are actinonin analogues lacking the pentyl side-chain.

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Article information

DOI
https://doi.org/10.1039/P19750000825
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1975, 825-830

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Studies concerning the antibiotic actinonin. Part II. Total synthesis of actinonin and some structural analogues by the isomaleimide method

N. H. Anderson, W. D. Ollis, J. E. Thorpe and A. D. Ward, J. Chem. Soc., Perkin Trans. 1, 1975, 825 DOI: 10.1039/P19750000825

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