Issue 8, 1995
From the journal:

Journal of the Chemical Society, Faraday Transactions

Photosensitization of DNA bases by 4(5)-nitroimidazole: a steady state and flash photolysis study

Maitrayee Basu Roy,   Parikshit C. Mandal,   Samita Basu  and  Sudhindra N. Bhattacharyya  

Abstract

UV photolysis and laser flash photolysis of 4(5)-nitroimidazole in the presence of thymine and/or uracil generates the respective glycols under conditions where the bases do not absorb any light. The reaction is mediated through the triplet state of 4(5)-nitroimidazole which generates a highly oxidizing N-centred radical. The radical has an absorption maximum at ca. 350 nm and reacts efficiently with the DNA bases resulting in the formation of glycols. The rate constant of reaction of the radical with the DNA bases and nucleosides is of the order of ca. 108 dm3 mol–1 s–1, the rate being slower with the nucleosides than with the free bases.

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Article information

DOI
https://doi.org/10.1039/FT9959101191
Article type
Paper

J. Chem. Soc., Faraday Trans., 1995,91, 1191-1196

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Photosensitization of DNA bases by 4(5)-nitroimidazole: a steady state and flash photolysis study

M. B. Roy, P. C. Mandal, S. Basu and S. N. Bhattacharyya, J. Chem. Soc., Faraday Trans., 1995, 91, 1191 DOI: 10.1039/FT9959101191

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