Issue 42, 2023
From the journal:

Organic & Biomolecular Chemistry

Reductive coupling of nitroarenes with carboxylic acids – a direct route to amide synthesis†

Mikhail A. Losev,‡ab   Andrey S. Kozlov,‡a   Vladimir B. Kharitonov,a   Oleg I. Afanasyev, ORCID logo a   Fedor S. Kliuev, ORCID logo ab   Ludmila A. Bulygina,a   Natalya S. Khrushcheva,a   Dmitry A. Loginova  and  Denis Chusov ORCID logo *ab  

* Corresponding authors

a A.N. Nesmeyanov Institute of Organoelement compounds of the Russian Academy of Sciences, Moscow, Russian Federation
E-mail: chusov@ineos.ac.ru

b National Research University Higher School of Economics, Moscow, 101000, Russian Federation

Abstract

A straightforward and selective way for the preparation of amides from nitroarenes and carboxylic acids using carbon monoxide as a reductant was developed. This protocol does not require any non-gaseous additives, thus simplifying product isolation. Aliphatic carboxylic acid was modified in the presence of aromatic ones, and reducible functional groups such as C[double bond, length as m-dash]C, Ar–Br, and R–NO2 were saved.

Graphical abstract: Reductive coupling of nitroarenes with carboxylic acids – a direct route to amide synthesis

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Article information

DOI
https://doi.org/10.1039/D3OB01452E
Article type
Communication
Submitted
09 Sep 2023
Accepted
05 Oct 2023
First published
05 Oct 2023

Org. Biomol. Chem., 2023,21, 8477-8481

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Reductive coupling of nitroarenes with carboxylic acids – a direct route to amide synthesis

M. A. Losev, A. S. Kozlov, V. B. Kharitonov, O. I. Afanasyev, F. S. Kliuev, L. A. Bulygina, N. S. Khrushcheva, D. A. Loginov and D. Chusov, Org. Biomol. Chem., 2023, 21, 8477 DOI: 10.1039/D3OB01452E

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