Issue 14, 2023
From the journal:

New Journal of Chemistry

Sodium hypophosphite mediated reductive amination of carbonyl compounds with N,N-dialkylformamides†

Artemy R. Fatkulin, ORCID logo ab   Vasily Korochantsev,abd   Oleg I. Afanasyev, ORCID logo ae   Evgeniya Podyacheva,ab   Olga Chusova,ac   Dmitry V. Muratov,a   Maria I. Godovikova,a   Sergei Semenovd  and  Denis Chusov ORCID logo *ab  

* Corresponding authors

a A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, INEOS, Vavilova St. 28, bld. 1, Moscow, Russia

b National Research University Higher School of Economics, Miasnitskaya Str. 20, Moscow 101000, Russian Federation

c Faculty of Science, RUDN University, 6 Miklukho-Maklaya St., Moscow, Russia

d Moscow South-Eastern School named after V.I. Chuikov (Moscow Chemical Lyceum), 4 Tamozhenniy proezd, 111033 Moscow, Russian Federation

e Plekhanov Russian University of Economics, Stremyanny per. 36, 117997 Moscow, Russian Federation

Abstract

Herein we report a transition-metal- and acid-free protocol for the reductive amination of carbonyl compounds with DMF using a substoichiometric amount of NaH2PO2·H2O. A set of various N,N-dimethylamines were obtained in moderate to excellent yields without chromatographic purification. The general trends and limitations of the method with different formamides as sources of dialkyl-fragments were explored.

Graphical abstract: Sodium hypophosphite mediated reductive amination of carbonyl compounds with N,N-dialkylformamides

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Article information

DOI
https://doi.org/10.1039/D3NJ00728F
Article type
Communication
Submitted
15 Feb 2023
Accepted
09 Mar 2023
First published
10 Mar 2023

New J. Chem., 2023,47, 6532-6535

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Sodium hypophosphite mediated reductive amination of carbonyl compounds with N,N-dialkylformamides

A. R. Fatkulin, V. Korochantsev, O. I. Afanasyev, E. Podyacheva, O. Chusova, D. V. Muratov, M. I. Godovikova, S. Semenov and D. Chusov, New J. Chem., 2023, 47, 6532 DOI: 10.1039/D3NJ00728F

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