Issue 17, 2022
From the journal:

Dalton Transactions

Ruthenium photosensitizer anchored gold nanorods for synergistic photodynamic and photothermal therapy†

Hongdong Shi,‡a   Simin Lin,‡a   Yi Wang,a   Jingxue Lou,a   Yatao Hu,a   Yuyu Chena  and  Qianling Zhang ORCID logo *a  

* Corresponding authors

a Graphene Composite Research Center, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518060, China
E-mail: zhql@szu.edu.cn

Abstract

Ruthenium polypyridyl complexes have been widely used as bioprobes and photosensitizers. However, several disadvantages including slow cellular uptake, nonspecific binding with biomolecules and toxicity limit their applications. In this study, a nanocarrier of human serum albumin coated gold nanorods was developed to deliver a ruthenium photosensitizer for PDT/PTT combination therapy. The HSA coating endowed the nanodrug with high biocompatibility and stability under physiological conditions. Ru-GNR-HSANPs generate 1O2 and hydroxyl radicals to kill cancer cells under blue light irradiation, and exhibit excellent photothermal anticancer effects under 808 nm light irradiation. Significant synergistic anticancer effects were achieved by combined PDT/PTT therapy. Importantly, Ru-GNR-HSANPs can have the synergistic PDT/PTT functions with no need of drug release from the carrier.

Graphical abstract: Ruthenium photosensitizer anchored gold nanorods for synergistic photodynamic and photothermal therapy

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Article information

DOI
https://doi.org/10.1039/D2DT00365A
Article type
Paper
Submitted
05 Feb 2022
Accepted
05 Apr 2022
First published
09 Apr 2022

Dalton Trans., 2022,51, 6846-6854

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Ruthenium photosensitizer anchored gold nanorods for synergistic photodynamic and photothermal therapy

H. Shi, S. Lin, Y. Wang, J. Lou, Y. Hu, Y. Chen and Q. Zhang, Dalton Trans., 2022, 51, 6846 DOI: 10.1039/D2DT00365A

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