SCHEDULED MAINTENANCE
Electrochemically produced local pH changes stimulating (bio)molecule release from pH-switchable electrode-immobilized avidin–biotin systems†
Ronaldo
Badenhorst, 
‡a
Vasantha Krishna
Kadambar,
‡a
Madhura
Bellare,
a
Artem
Melman,
§a
Evgeny
Katz
*a
and
Oleh
Smutok
*a
‡a
Vasantha Krishna
Kadambar,
‡a
Madhura
Bellare,
a
Artem
Melman,
§a
Evgeny
Katz
*a
and
Oleh
Smutok
*a
Abstract
Immobilized avidin–biotin complexes were used to release biotinylated (bio)molecules upon producing local pH changes near an electrode surface by electrochemical reactions. The nitro-avidin complex with biotin was dissociated by increasing local pH with electrochemical O2 reduction. The avidin complex with iminobiotin was split by decreasing local pH with electrochemical oxidation of ascorbate. Both studied systems were releasing molecule cargo species in response to small electrical potentials (−0.4 V or 0.2 V for the O2 reduction or ascorbate oxidation, respectively) applied on the modified electrodes.
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